Ching-Hsiang Fan

Assistant Professor

Department of Biomedical Engineering
National Cheng Kung University
1. Tashueh Rd., Tainan City 701, Taiwan

10908013@gs.ncku.edu.tw

Degrees

l   B. S., Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taiwan., 2003-2007

l   M. S., Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan, 2008-2010

l   Ph.D., Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan, 2010-2013

Research Areas

l   Therapeutic Ultrasound

l   Drug Delivery

l   Ultrasound Responsible Contrast Agent Design

l   Ultrasound Imaging Processing

Work Experience

l   Assistant Professor, Department of Biomedical Engineering, National Cheng Kung University                                                    2020-persent

l   Postdoctoral Researcher, Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan                                                   2013-2020

Awards and Recognitions

2019 Young Scholar Fellowships (The Columbus Program)

2020 Young Investigator Award, An An Slow Angel’s Family Support Association, Yi-Lan, Taiwan

2017

2017 Young Investigator Award, An An Slow Angel’s Family Support Association, Yi-Lan, Taiwan

2014 Poster Competition Award, 2014 The 6th Asian Conference on Ultrasound Contrast Imaging

2013 Taiwan-Japan Summer Program, Ministry of Science and Technology, Japan-Taiwan Exchange Association

2012 Student travel support, 2012 IEEE international ultrasound symposium

2012 Oral Competition Award, 2012 Annual symposium on Biomedical Engineering and Technology

2009 Poster Competition Award, 2009 Annual symposium on Biomedical Engineering and Technology

Publications in the recent 5 Years (2016-2020)

Journal:

1. Yi-Ju Ho, Ju-Pi Li, Ching-Hsiang Fan, Hao-Li Liu, and Chih-Kuang Yeh, Ultrasound in Tumor Immunotherapy: Current Status and Future Developments. Journal of Controlled Release, 2020 Apr, 323:12-23, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 0.

2. Yi-Ju Ho, Hui-Ching Hsu, Shih-Tsung Kang, Ching-Hsiang Fan, Chien-Wen Chang, and Chih-Kuang Yeh, Ultrasonic Transdermal Delivery System with Acid-Base Neutralization-Generated CO2 Microbubble Cavitation. ACS Appl. Bio Mater. 2020 Mar, 4, 1968-1975. Cited: 0.

3. Chun-Yao Wu, Rih-Yang Huang, En-Chi Liao, Yu-Chun Lin, Yi-Ju Ho, Chien-Wen Chang, Hong-Lin Chan, Ying-Zu Huang, Tsung-Hsun Hsieh, Ching-Hsiang Fan*, and Chih-Kuang Yeh*, A preliminary study of Parkinson’s gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice. Brain Stimul. 2020 Feb, 13:786-799, IF: 6.919, Neurosciences, 22/267. Cited: 0.

4. Chun-Yao Wu*, Ching-Hsiang Fan*, Nai-Hua Chiu, Yi-Ju Ho, Yu-Chun Lin and Chih-Kuang Yeh, Targeted delivery of engineered auditory sensing protein for ultrasound neuromodulation in the brain. Theranostics, 2019. Feb, 10:3546-3561 IF: 8.651, Medicine, Research & Experimental, 8/128. Cited: 0.

5. Yao-Shen Huang*, Ching-Hsiang Fan*, Ning Hsu*, Nai-Hua Chiu, Chun-Yao Wu, Chu-Yuan Chang, Bing-Huan Wu, Shi-Rong Hong, Ya-Chu Chang, Anthony Yan-Tang Wu, Vanessa Guo, Yueh-Chen Chiang, Wei-Chia Hsu, Linyi Chen, Charles Pin-Kuang Lai, Chih-Kuang Yeh, and Yu-Chun Lin, Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein, Nano Lett, 2020 Jan, 20:1089-1100. IF: 13.969, Nanoscience & Nanotechnology, 10/94. Cited: 2.

6. Hsiang-Ching Lin, Ching-Hsiang Fan, Yi-Ju Ho, and Chih-Kuang Yeh, Dual-Frequency Chirp Excitation for Passive Cavitation Imaging in the Brain, IEEE Trans Ultrason Ferroelectr Freq Control, 2020 Jan, IF: 2.989, Acoustics, 6/31.  Cited: 0.

7. Yi-Ju Ho, Cheng-Han Wu, Qiao-Feng Jin, Chih-Yu Lin, Pei-Hua Chiang, Nan Wu, Ching-Hsiang Fan, Chia-Min Yang, and Chih-Kuang Yeh, Superhydrophobic Drug-Loaded Mesoporous Silica Nanoparticles Capped With β-Cyclodextrin for Ultrasound Image-Guided Combined Antivascular and Chemo-Sonodynamic Therapy, Biomaterials, 2019 Dec,232:119723, IF: 9.550, Engineering, Biomedical, 2/77. Cited: 0.

8. Yi-Ju Ho, Shu-Wei Chu, En-Chi Liao, Ching-Hsiang Fan, Hong-Lin Chan, Kuo-Chen Wei, and Chih-Kuang Yeh, Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound, Theranostics, 2019 Sep 25;9(24):7370-7383, IF: 8.651, Medicine, Research & Experimental, 8/128. Cited: 0.

9. Chen‐Hua Wu, Hao‐Li Liu, Cheng‐Tao Ho, Po‐Hung Hsu, Ching‐Hsiang Fan, Chih‐Kuang Yeh, Shih‐Tsung Kang, Wen‐Shiang Chen, Fu‐Nien Wang, and Hsu‐Hsia Peng, Monitoring of acoustic cavitation in microbubble‐presented focused ultrasound exposure using gradient‐echo MRI, J Magn Reson Imaging. 2019 May 24, IF: 3.570, Radiology, 26/129. Cited: 0.

10. Tai-Tzung Kuo, Chung-Hsin Wang, Jir-You Wang, Hong-Jen Chiou, Ching-Hsiang Fan and Chih-Kuang Yeh, Concurrent Osteosarcoma Theranostic Strategy Using Contrast-Enhanced Ultrasound and Drug-Loaded Bubbles, Pharmaceutics. 2019 May 11: E223, IF: 4.773, Pharmacology & Pharmacy, 26/267. Cited: 1.

11. Ching-Hsiang Fan, Ta-Wei Wang, Yi-Kong Hsieh, Chu-Fang Wang, Zhenyu Gao, Ahram Kim, Yukio Nagasaki, and Chih-Kuang Yeh, Enhancing Boron Uptake in Brain Glioma Treatment by Boron-polymer/Microbubble Complex with Ultrasound, ACS Appl Mater Interfaces, 2019 Mar, 11: 11144-11156, IF: 8.694, Material Science & Multidiscriplinary, 26/285. Cited: 7.

12. Ching-Hsiang Fan, Yi-Ting Lin, Yi-Ju Ho, and Chih-Kuang Yeh, Spatial-Temporal Cellular Bioeffects from Acoustic Droplet Vaporization, Theranostics, 2018 Nov, 8: 5731-5743, IF: 8.651, Medicine, Research & Experimental, 8/128. Cited: 1.

13. Yi-Ju Ho, Chin-Chou Wu, Zong-Han Hsieh, Ching-Hsiang Fan, and Chih-Kuang Yeh, Thermal-sensitive acoustic droplets for dual-mode ultrasound imaging and drug delivery, Journal of Controlled Release, 2018 Dec, 291:26-36, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 2.

14. Yi-Ju Ho, Tzu-Chia Wang, Ching-Hsiang Fan, and Chih-Kuang Yeh, Spatially Uniform Tumor Treatment and Drug Penetration by Regulating Ultrasound with Microbubbles, ACS Appl Mater Interfaces. 2018 May, 10:17784-17791, IF: 8.694, Material Science & Multidiscriplinary, 26/285. Cited: 10.

15. Ching-Hsiang Fan, Ya-Hsuan Lee, Yi-Ju Ho, Chung-Hsin Wang, Shih-Tsung Kang, and Chih-Kuang Yeh, Macrophages as drug delivery carriers for acoustic phase-change droplets, Ultrasound in Medicine & Biology, 2018 Jul, 44:1468-1481, IF: 2.633, Acoustics, 6/31. Cited: 2.                                

16. Yi-Ju Ho, Yu-Jung Chiang, Shih-Tsung Kang, Ching-Hsiang Fan, and Chih-Kuang Yeh, Camptothecin-loaded fusogenic nanodroplets as ultrasound theranostic agent in stem cell-mediated drug-delivery system, Journal of Controlled Release, 2018 Apr, 10;278:100-109, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 7.

17. Ching-Hsiang Fan, Yao-Shen Huang, Wei-En Huang, Albert Alexander Lee, Sheng-Yang Ho,Yu-Lin Kao, Cuei-Ling Wang, Yen-Ling Lian, Tasuku Ueno, Tsung-Shing Andrew Wang, Chih-Kuang Yeh, and Yu-Chun Lin, Manipulating Cellular Activities Using an Ultrasound-Chemical Hybrid Tool, ACS Synth Biol, 2017 Nov, 6, 2021-2027, IF: 5.905, Biochemical research methods, 7/78. Cited: 0.

18. Yi-Ju Ho, Tzu-Chia Wang, Ching-Hsiang Fan, Chih-Kuang Yeh, Current progress in antivascular tumor therapy, Drug Discov Today, 2017 Oct, 22:1503-1515, IF: 6.820, Pharmacology & Pharmacy, 16/257. Cited: 12.

19. Ching-Hsiang Fan, Chung-Yin Lin, Hao-Li Liu, and Chih-Kuang Yeh, Ultrasound targeted CNS gene delivery for Parkinson's disease treatment, Journal of Controlled Release, 2017 Sep, 10;261:246-262, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 30.

20. En-Ling Chang, Chien-Yu Ting, Po-Hung Hsu, Yu-Chun Lin, En-Chi Liao, Chih-Ying Huang, Yuan-Chih Chang, Hong-Lin Chan, Chi-Shiun Chiang, Hao-Li Liu, Kuo-Chen Wei, Ching-Hsiang Fan* and Chih-Kuang Yeh*, Angiogenesis-targeting Microbubbles Combined with Ultrasound-Mediated Gene Therapy in Brain Tumors. Journal of Controlled Release, 2017 Jun, 10;255:164-175, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 19.

21. Sheng-Kai Wu, Po-Chun Chu, Wen-Yen Chai, Shih-Tsung Kang, Chih-Hung Tsai, Ching-Hsiang Fan, Chih-Kuang Yeh, and Hao-Li Liu, Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening, Scientific Reports, 2017 Apr, 7:46689, IF: 4.525, Multidisciplinary Sciences, 10/64. Cited: 33.

22. Ching-Hsiang Fan, En-Ling Chang, Chien-Yu Ting, Yu-Chun Lin, En-Chi Liao, Chiung-Yin Huang, Yuan-Chih Chang, Hong-Lin Chan, Kuo-Chen Wei, and Chih-Kuang Yeh, Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery, Biomaterials, 2016 Jan,106:46-57, IF: 9.550, Engineering, Biomedical, 2/77. Cited: 43.

23. Ching-Hsiang Fan, Yu-Hang Cheng, Chien-Yu Ting, Yi-Ju Ho, Po-Hung Hsu, Hao-Li Liu, and Chih-Kuang Yeh, Ultrasound/Magnetic Targeting with SPIO-DOX Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors, Theranostics, 2016 Jan, 6:1542-1556, IF: 8.651, Medicine, Research & Experimental, 8/128. Cited: 52.

24. Ching-Hsiang Fan, Chien-Yu Ting, Chung‐Yin Lin, Hong-Lin Chan, Yuan-Chih Chang, You-Yin Chen, Hao-Li Liu, and Chih-Kuang Yeh, Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease, Scientific Reports, 2016 Jan, 6:19579, IF: 4.525, Multidisciplinary Sciences, 10/64. Cited: 46.

Conference:

1. Ching-Hsiang Fan, Yao-Shen Huang, Yu-Chun Lin, Chih-Kuang Yeh (2019, Sep). Modulation of cellular activities using an engineered auditory-sensing protein with ultrasound. 2019 IEEE International Ultrasonics Symposium, Glasgow, United Kingdom. (Oral presentation).

2. Ching-Hsiang Fan, Nai-Hua Chiu, Yu-Chun Lin, Chih-Kuang Yeh (2019, Sep). Targeted Delivery of Electromechanical Protein Prestin to the Brain Using Ultrasound. 2019 IEEE International Ultrasonics Symposium, Glasgow, United Kingdom. (Poster presentation).

3. Ching-Hsiang Fan, Yi-Ting Lin, Yu-Chun Lin, Chih-Kuang Yeh (2018, Sep). Acoustic droplet vaporization induced physicochemical effects at the single-cell level. 2018 IEEE International Ultrasonics Symposium, Kobe, Japan. (Poster presentation).

4. Chun-Yao Wu, Ching-Hsiang Fan, Rih-Yang Huang, Chien-Wen Chang, Chih-Kuang Yeh (2018, Sep). Ultrasonic-magnetic Hybrid Gene-delivery System for Parkinson’s Disease Treatment. 2018 IEEE International Ultrasonics Symposium, Kobe, Japan. (Poster presentation).

5. Ching-Hsiang Fan, Yao-Shen Huang, Yu-Chun Lin, Chih-Kuang Yeh (2017, Sep). Ultrasound-chemical hybrid system for manipulating cellular activities. 2017 IEEE International Ultrasonics Symposium, DC, USA. (Poster presentation)

6. Ching-Hsiang Fan, Yu-Hang Cheng, Chien-Yu Ting, Yi-Ju Ho, Po-Hung Hsu, Hao-Li Liu, Chih-Kuang Yeh (2016, Sep). SPIO-DOX-Microbubble Complex with Ultrasound for MRI Image-Guided Drug Delivery in a rat glioma model. 2016 IEEE International Ultrasonics Symposium, Tours, France. (Poster presentation)