范景翔

助理教授

國立清華大學
生醫工程與環境科學系博士

治療用超音波
藥物遞送
超音波對比劑開發
影像處理

姓名

范景翔

職稱

助理教授

辦公室

成杏校區醫工大樓一樓室

聯絡電話

06-2757575

傳真

E-Mail

10908013@gs.ncku.edu.tw

實驗室

超音波與藥物控制釋放實驗室

學歷

中山醫學大學 醫學影像暨放射科學系 學士, 2003-2007
國立清華大學 生醫工程與環境科學系 碩士, 2008-2010
國立清華大學 生醫工程與環境科學系 博士, 2010-2013

經歷

國立成功大學 醫工系 助理教授 2020~迄今
國立清華大學 生醫工程與環境科學系 博士後研究員 2013~2020

研究專長

治療用超音波
藥物遞送
超音波對比劑開發
影像處理

近年榮譽與獲獎 (2009-2020)

50. 109年輕學者養成計畫 (109年度哥倫布計畫)。
50. 2020 安安慢飛天使 神經精神科學勵翔獎 入選 (宜蘭縣安安慢飛天使家庭關懷協會)，
50. 2017 績優替代役男 (中華民國內政部役政署)。
50. 2017 安安慢飛天使 神經精神科學勵翔獎 (宜蘭縣安安慢飛天使家庭關懷協會) (http://www.ananaward.org.tw/?page_id=55)
50. Poster Competition Award (2014 The 6th Asian Conference on Ultrasound Contrast Imaging)。
50. 2013選送博士生暑期赴日研究計畫 (行政院國家科學委員會與公益財團法人日本交流協會)。
50. Student travel support (2012 IEEE international ultrasound symposium)
50. 2012 生物醫學工程科技研討會 學生口頭發表競賽 優等
50. 2009 生物醫學工程科技研討會 學生海報發表競賽 優等

近五年著作與專利 (2016-2020)

期刊論文:

1. Yi-Ju Ho, Ju-Pi Li, Ching-Hsiang Fan, Hao-Li Liu, and Chih-Kuang Yeh, Ultrasound in Tumor Immunotherapy: Current Status and Future Developments. Journal of Controlled Release, 2020 Apr, 323:12-23, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 0.

2. Yi-Ju Ho, Hui-Ching Hsu, Shih-Tsung Kang, Ching-Hsiang Fan, Chien-Wen Chang, and Chih-Kuang Yeh, Ultrasonic Transdermal Delivery System with Acid-Base Neutralization-Generated CO2 Microbubble Cavitation. ACS Appl. Bio Mater. 2020 Mar, 4, 1968-1975. Cited: 0.

3. Chun-Yao Wu, Rih-Yang Huang, En-Chi Liao, Yu-Chun Lin, Yi-Ju Ho, Chien-Wen Chang, Hong-Lin Chan, Ying-Zu Huang, Tsung-Hsun Hsieh, Ching-Hsiang Fan*, and Chih-Kuang Yeh*, A preliminary study of Parkinson’s gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice. Brain Stimul. 2020 Feb, 13:786-799, IF: 6.919, Neurosciences, 22/267. Cited: 0.

4. Chun-Yao Wu*, Ching-Hsiang Fan*, Nai-Hua Chiu, Yi-Ju Ho, Yu-Chun Lin and Chih-Kuang Yeh, Targeted delivery of engineered auditory sensing protein for ultrasound neuromodulation in the brain. Theranostics, 2019. Feb, 10:3546-3561 IF: 8.651, Medicine, Research & Experimental, 8/128. Cited: 0.

5. Yao-Shen Huang*, Ching-Hsiang Fan*, Ning Hsu*, Nai-Hua Chiu, Chun-Yao Wu, Chu-Yuan Chang, Bing-Huan Wu, Shi-Rong Hong, Ya-Chu Chang, Anthony Yan-Tang Wu, Vanessa Guo, Yueh-Chen Chiang, Wei-Chia Hsu, Linyi Chen, Charles Pin-Kuang Lai, Chih-Kuang Yeh, and Yu-Chun Lin, Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein, Nano Lett, 2020 Jan, 20:1089-1100. IF: 13.969, Nanoscience & Nanotechnology, 10/94. Cited: 2.

6. Hsiang-Ching Lin, Ching-Hsiang Fan, Yi-Ju Ho, and Chih-Kuang Yeh, Dual-Frequency Chirp Excitation for Passive Cavitation Imaging in the Brain, IEEE Trans Ultrason Ferroelectr Freq Control, 2020 Jan, IF: 2.989, Acoustics, 6/31.  Cited: 0.

7. Yi-Ju Ho, Cheng-Han Wu, Qiao-Feng Jin, Chih-Yu Lin, Pei-Hua Chiang, Nan Wu, Ching-Hsiang Fan, Chia-Min Yang, and Chih-Kuang Yeh, Superhydrophobic Drug-Loaded Mesoporous Silica Nanoparticles Capped With β-Cyclodextrin for Ultrasound Image-Guided Combined Antivascular and Chemo-Sonodynamic Therapy, Biomaterials, 2019 Dec,232:119723, IF: 9.550, Engineering, Biomedical, 2/77. Cited: 0.

8. Yi-Ju Ho, Shu-Wei Chu, En-Chi Liao, Ching-Hsiang Fan, Hong-Lin Chan, Kuo-Chen Wei, and Chih-Kuang Yeh, Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound, Theranostics, 2019 Sep 25;9(24):7370-7383, IF: 8.651, Medicine, Research & Experimental, 8/128. Cited: 0.

9. Chen‐Hua Wu, Hao‐Li Liu, Cheng‐Tao Ho, Po‐Hung Hsu, Ching‐Hsiang Fan, Chih‐Kuang Yeh, Shih‐Tsung Kang, Wen‐Shiang Chen, Fu‐Nien Wang, and Hsu‐Hsia Peng, Monitoring of acoustic cavitation in microbubble‐presented focused ultrasound exposure using gradient‐echo MRI, J Magn Reson Imaging. 2019 May 24, IF: 3.570, Radiology, 26/129. Cited: 0.

10. Tai-Tzung Kuo, Chung-Hsin Wang, Jir-You Wang, Hong-Jen Chiou, Ching-Hsiang Fan and Chih-Kuang Yeh, Concurrent Osteosarcoma Theranostic Strategy Using Contrast-Enhanced Ultrasound and Drug-Loaded Bubbles, Pharmaceutics. 2019 May 11: E223, IF: 4.773, Pharmacology & Pharmacy, 26/267. Cited: 1.

11. Ching-Hsiang Fan, Ta-Wei Wang, Yi-Kong Hsieh, Chu-Fang Wang, Zhenyu Gao, Ahram Kim, Yukio Nagasaki, and Chih-Kuang Yeh, Enhancing Boron Uptake in Brain Glioma Treatment by Boron-polymer/Microbubble Complex with Ultrasound, ACS Appl Mater Interfaces, 2019 Mar, 11: 11144-11156, IF: 8.694, Material Science & Multidiscriplinary, 26/285. Cited: 7.

12. Ching-Hsiang Fan, Yi-Ting Lin, Yi-Ju Ho, and Chih-Kuang Yeh, Spatial-Temporal Cellular Bioeffects from Acoustic Droplet Vaporization, Theranostics, 2018 Nov, 8: 5731-5743, IF: 8.651, Medicine, Research & Experimental, 8/128. Cited: 1.

13. Yi-Ju Ho, Chin-Chou Wu, Zong-Han Hsieh, Ching-Hsiang Fan, and Chih-Kuang Yeh, Thermal-sensitive acoustic droplets for dual-mode ultrasound imaging and drug delivery, Journal of Controlled Release, 2018 Dec, 291:26-36, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 2.

14. Yi-Ju Ho, Tzu-Chia Wang, Ching-Hsiang Fan, and Chih-Kuang Yeh, Spatially Uniform Tumor Treatment and Drug Penetration by Regulating Ultrasound with Microbubbles, ACS Appl Mater Interfaces. 2018 May, 10:17784-17791, IF: 8.694, Material Science & Multidiscriplinary, 26/285. Cited: 10.

15. Ching-Hsiang Fan, Ya-Hsuan Lee, Yi-Ju Ho, Chung-Hsin Wang, Shih-Tsung Kang, and Chih-Kuang Yeh, Macrophages as drug delivery carriers for acoustic phase-change droplets, Ultrasound in Medicine & Biology, 2018 Jul, 44:1468-1481, IF: 2.633, Acoustics, 6/31. Cited: 2.                                

16. Yi-Ju Ho, Yu-Jung Chiang, Shih-Tsung Kang, Ching-Hsiang Fan, and Chih-Kuang Yeh, Camptothecin-loaded fusogenic nanodroplets as ultrasound theranostic agent in stem cell-mediated drug-delivery system, Journal of Controlled Release, 2018 Apr, 10;278:100-109, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 7.

17. Ching-Hsiang Fan, Yao-Shen Huang, Wei-En Huang, Albert Alexander Lee, Sheng-Yang Ho,Yu-Lin Kao, Cuei-Ling Wang, Yen-Ling Lian, Tasuku Ueno, Tsung-Shing Andrew Wang, Chih-Kuang Yeh, and Yu-Chun Lin, Manipulating Cellular Activities Using an Ultrasound-Chemical Hybrid Tool, ACS Synth Biol, 2017 Nov, 6, 2021-2027, IF: 5.905, Biochemical research methods, 7/78. Cited: 0.

18. Yi-Ju Ho, Tzu-Chia Wang, Ching-Hsiang Fan, Chih-Kuang Yeh, Current progress in antivascular tumor therapy, Drug Discov Today, 2017 Oct, 22:1503-1515, IF: 6.820, Pharmacology & Pharmacy, 16/257. Cited: 12.

19. Ching-Hsiang Fan, Chung-Yin Lin, Hao-Li Liu, and Chih-Kuang Yeh, Ultrasound targeted CNS gene delivery for Parkinson's disease treatment, Journal of Controlled Release, 2017 Sep, 10;261:246-262, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 30.

20. En-Ling Chang, Chien-Yu Ting, Po-Hung Hsu, Yu-Chun Lin, En-Chi Liao, Chih-Ying Huang, Yuan-Chih Chang, Hong-Lin Chan, Chi-Shiun Chiang, Hao-Li Liu, Kuo-Chen Wei, Ching-Hsiang Fan* and Chih-Kuang Yeh*, Angiogenesis-targeting Microbubbles Combined with Ultrasound-Mediated Gene Therapy in Brain Tumors. Journal of Controlled Release, 2017 Jun, 10;255:164-175, IF: 8.375, Pharmacology & Pharmacy, 10/257. Cited: 19.

21. Sheng-Kai Wu, Po-Chun Chu, Wen-Yen Chai, Shih-Tsung Kang, Chih-Hung Tsai, Ching-Hsiang Fan, Chih-Kuang Yeh, and Hao-Li Liu, Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening, Scientific Reports, 2017 Apr, 7:46689, IF: 4.525, Multidisciplinary Sciences, 10/64. Cited: 33.

22. Ching-Hsiang Fan, En-Ling Chang, Chien-Yu Ting, Yu-Chun Lin, En-Chi Liao, Chiung-Yin Huang, Yuan-Chih Chang, Hong-Lin Chan, Kuo-Chen Wei, and Chih-Kuang Yeh, Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery, Biomaterials, 2016 Jan,106:46-57, IF: 9.550, Engineering, Biomedical, 2/77. Cited: 43.

23. Ching-Hsiang Fan, Yu-Hang Cheng, Chien-Yu Ting, Yi-Ju Ho, Po-Hung Hsu, Hao-Li Liu, and Chih-Kuang Yeh, Ultrasound/Magnetic Targeting with SPIO-DOX Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors, Theranostics, 2016 Jan, 6:1542-1556, IF: 8.651, Medicine, Research & Experimental, 8/128. Cited: 52.

24. Ching-Hsiang Fan, Chien-Yu Ting, Chung‐Yin Lin, Hong-Lin Chan, Yuan-Chih Chang, You-Yin Chen, Hao-Li Liu, and Chih-Kuang Yeh, Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease, Scientific Reports, 2016 Jan, 6:19579, IF: 4.525, Multidisciplinary Sciences, 10/64. Cited: 46.

會議論文:

1. Ching-Hsiang Fan, Yao-Shen Huang, Yu-Chun Lin, Chih-Kuang Yeh (2019, Sep). Modulation of cellular activities using an engineered auditory-sensing protein with ultrasound. 2019 IEEE International Ultrasonics Symposium, Glasgow, United Kingdom. (Oral presentation).

2. Ching-Hsiang Fan, Nai-Hua Chiu, Yu-Chun Lin, Chih-Kuang Yeh (2019, Sep). Targeted Delivery of Electromechanical Protein Prestin to the Brain Using Ultrasound. 2019 IEEE International Ultrasonics Symposium, Glasgow, United Kingdom. (Poster presentation).

3. Ching-Hsiang Fan, Yi-Ting Lin, Yu-Chun Lin, Chih-Kuang Yeh (2018, Sep). Acoustic droplet vaporization induced physicochemical effects at the single-cell level. 2018 IEEE International Ultrasonics Symposium, Kobe, Japan. (Poster presentation).

4. Chun-Yao Wu, Ching-Hsiang Fan, Rih-Yang Huang, Chien-Wen Chang, Chih-Kuang Yeh (2018, Sep). Ultrasonic-magnetic Hybrid Gene-delivery System for Parkinson’s Disease Treatment. 2018 IEEE International Ultrasonics Symposium, Kobe, Japan. (Poster presentation).

5. Ching-Hsiang Fan, Yao-Shen Huang, Yu-Chun Lin, Chih-Kuang Yeh (2017, Sep). Ultrasound-chemical hybrid system for manipulating cellular activities. 2017 IEEE International Ultrasonics Symposium, DC, USA. (Poster presentation)

6. Ching-Hsiang Fan, Yu-Hang Cheng, Chien-Yu Ting, Yi-Ju Ho, Po-Hung Hsu, Hao-Li Liu, Chih-Kuang Yeh (2016, Sep). SPIO-DOX-Microbubble Complex with Ultrasound for MRI Image-Guided Drug Delivery in a rat glioma model. 2016 IEEE International Ultrasonics Symposium, Tours, France. (Poster presentation)